Structure and Activation of Soluble Guanylyl Cyclase, the Nitric Oxide Sensor
نویسندگان
چکیده
منابع مشابه
Nitric oxide activation of guanylyl cyclase in cells revisited.
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A major receptor for nitric oxide (NO) is the cGMP-synthesizing enzyme, soluble guanylyl cyclase (sGC), but it is not known how this enzyme behaves in cells. In cerebellar cells, NO (from diethylamine NONOate) increased astrocytic cGMP with a potency (EC(50) </= 20 nM) higher than that reported for purified sGC. Deactivation of NO-stimulated sGC activity, studied by trapping free NO with hemogl...
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ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2017
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2016.6693